New COVID-19 Vaccines Targeting KP.2 Variant Available
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New COVID-19 vaccines formulated for better protection against the currently circulating variants have been approved by the US Food and Drug Administration.
The COVID vaccines available this fall have been updated to better match the currently circulating COVID strains, said William Schaffner, MD, professor of medicine in the Division of Infectious Diseases at Vanderbilt University, Nashville, Tennessee, in an interview. "The Pfizer and Moderna vaccines — both mRNA vaccines — target the KP.2 variant, while the Novavax vaccine targets the JN.1 variant, which is a predecessor to KP.2," said Schaffner, who also serves as a spokesperson for the National Foundation for Infectious Diseases. "The Novavax vaccine is a protein adjuvant vaccine made in a more traditional fashion and may appeal to those who remain hesitant about receiving an mRNA vaccine," he explained. However, all three vaccines are designed to protect against severe COVID illness and reduce the likelihood of hospitalization, he said. Who Needs It?"The CDC's Advisory Committee on Immunization Practices (ACIP) continues to recommend that everyone in the United States who is age 6 months and older receive the updated COVID vaccine this fall, along with influenza vaccine," Schaffner said. "This was not a surprise because COVID will produce a sizable winter outbreak," he predicted. Although older people and those who have chronic medical conditions such as heart or lung disease, diabetes, or other immunocompromising conditions suffer the most serious impact of COVID, he said. "The virus can strike anyone, even the young and healthy." The risk for long COVID persists as well, he pointed out. The ACIP recommendation is endorsed by the American Academy of Pediatrics and other professional organizations, Shaffner said. A frequently asked question is whether the COVID and flu vaccines can be given at the same time, and the answer is yes, according to a statement from the Centers for Disease Control and Prevention (CDC). "The optimal time to be vaccinated is late September and anytime during October in order to get the benefit of protection through the winter," Schaffner said. As with earlier versions of the COVID-19 vaccine, side effects vary from person to person. Reported side effects of the updated vaccine are similar to those seen with earlier versions and may include injection site pain, redness and swelling, fatigue, headache, muscle pain, chills, nausea, and fever, but most of these are short-lived, according to the CDC. Clinical GuidanceThe CDC's clinical guidance for COVID-19 vaccination outlines more specific guidance for vaccination based on age, vaccination history, and immunocompromised status and will be updated as needed. Schaffner strongly encouraged clinicians to recommend the COVID-19 vaccination for all eligible patients. "COVID is a nasty virus that can cause serious disease in anyone," and protection from previous vaccination or prior infection has likely waned, he said. Schaffner also encouraged healthcare professionals and their families to lead by example. "We should all be vaccinated and let our patients know that we are vaccinated and that we want all our patents to be protected," he said. The updated COVID-19 vaccination recommendations have become much simpler for clinicians and patients, with a single messenger RNA (mRNA) vaccine required for anyone older than 5 years, said David J. Cennimo, MD, associate professor of medicine & pediatrics in the Division of Infectious Disease at Rutgers New Jersey Medical School, Newark, New Jersey, in an interview. "The recommendations are a bit more complex for children < 5 years old receiving their first vaccination; they require two to three doses depending on the brand," he said. "It is important to review the latest recommendations to plan the doses with the correct interval timing. Considering the doses may be 3-4 weeks apart, start early," he advised. One-Time DosingAlthough the updated mRNA vaccine is currently recommended as a one-time dose, Cennimo said he can envision a scenario later in the season when a second dose is recommended for the elderly and those at high risk for severe illness. Cennimo said that he strongly agrees with the recommendations that everyone aged 6 months and older receive an updated COVID-19 vaccine. Older age remains the prime risk factor, but anyone can become infected, he said.
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